The cognitive improvements correlated to increased ALFF of the left medial prefrontal cortex, and increased FC of right medial prefrontal cortex and right ventral anterior cingulate cortex.Ĭonclusion: 10 Hz rTMS at DLPFC could improve cognitive function and quality of life for PSCI patients, which is associated with an altered frontal cortical activity.Ĭlinical Registration: Chinese Clinical Trial Registry, ChiCTR-IPR-17011908. Results: rTMS improved cognitive functions and ADLs for PSCI patients relative to patients who received no-stim control treatment. The amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) were applied as the analytical approaches, which were used to measure the resting-state brain activity and functional connection. 14 patients received functional MRI scan, a useful non-invasive technique of determining how structurally segregated and functionally specialized brain areas were interconnected, which was reflected by blood oxygenation level–dependent signals. Cognitive function was evaluated with the Montreal Cognitive Assessment Scale, Victoria Stroop Test, Rivermead Behavior Memory Test, and Activities of Daily Living (ADL) assessed with the Modified Barthel Index. Methods: We recruited 34 PSCI patients for 20 sessions of 10 Hz rTMS or no-stim control treatments over the left dorsal lateral prefrontal cortex (DLPFC). Objective: To identify the effects of rTMS intervention on PSCI patients and its potential neural correlates to behavioral improvements. 2Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Chinaīackground: Repetitive transcranial magnetic stimulation (rTMS) has been employed for motor function rehabilitation for stroke patients, but its effects on post-stroke cognitive impairment (PSCI) remains controversial.1Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.Mingyu Yin 1† Yuanwen Liu 1† Liying Zhang 1 Haiqing Zheng 1 Lingrong Peng 2 Yinan Ai 1 Jing Luo 1* Xiquan Hu 1*
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